Matrix Dynamics Lab

Research Facility



Matrix Dynamics Lab
University of New Brunswick, Fredericton
Fredericton
New Brunswick (NB)

Research in the Matrix Dynamics Lab focuses on the the emergence of tissue architecture during embryonic development, its regeneration during wound healing, and how cells generate mesoscopic 3D structures by modifying the extracellular matrix (ECM).  The major cellular effectors of ECM remodelling are the matrix metalloproteinases - a complex family of zinc-dependent proteases collectively capable of digesting all of the protein components of the ECM.  The regulation of MMP activity is excruciatingly complex, and is central to the normal and pathological remodelling of the ECM.  We have developed a variety of novel techniques that allow us to visualize the activity of MMPs, and crucial regulatory processes governing these activities, in the zebrafish embryo.  We use high performance computing for advanced image processing, structural chemistry modelling, and bioinformatics analysis as part of this research.

  • Biological and Life Sciences
  • Biomedical
  • Chemistry and Biochemistry
  • Biomedical
  • Biotechnology
  • Environmental Technologies and Related Services
  • Fisheries and Aquaculture
  • Life Sciences, Pharmaceuticals and Medical Equipment

Contacts



Bryan Crawford
bryanc@unb.ca
5064534583
Director

Equipment



Confocal Microscope
Leica
SP8

Super Resolution/ Super Sensitivity Microscopy

1 HyD

2 PMT's


Zebrafish Facility

Containment for wildtype and transgenic zebrafish

Lab has the ability to create transgenics


Standard Microbiology equipment for CRISPR/Cas9

To perform CRISPR/Cas9 research

Gel electrophoresis, PCR machines, centrifuges, incubators, water baths, etc.


Stereo Fluorescence Microscope
Leica
M205FA

Bright and high resolution microscopy for flourencent samples

Date submitted: Thu, Jul 26, 2018 10:42 AM
Date updated: Thu, Jul 26, 2018 10:48 AM

2018-07-26T10:48:12+00:00