Biomedical Translational Imaging Centre (BIOTIC)

Research Facility



Biomedical Translational Imaging Centre (BIOTIC)
NSHA & IWK
Halifax
Nova Scotia (NS)

BIOTIC (Biomedical Translational Imaging Centre) is a multi-site imaging centre that is embedded in the two leading research and teaching hospitals in Nova Scotia. Our advanced pre-clinical and clinical imaging equipment are housed in three labs encompassing over 12,000 square feet of lab space. Our equipment includes MRI, PET/CT, SPECT, EEG and MEG. We are the only group in Atlantic Canada with a collection of research-dedicated imaging technologies of this magnitude.

Our multidisciplinary and cross-functional teams, providing expertise in all facets of imaging research and development, collaborate on commercial development projects with industry partners, as well as research and development projects with a number of institutions. Our team is involved in co-developing medical technologies, as well as creating new imaging techniques and methods for diagnosing and monitoring treatment.

BIOTIC provides single-point access to the expertise, equipment, support services, clinicians, and patient populations you need to answer your most pressing research questions. We will work with you to advance your research program and move your discoveries along the path toward real-world application and commercialization.

  • Biomedical
  • Biotechnology
  • Medical Sciences
  • Biomedical
  • Biotechnology
  • Health Care and Social Services
  • Life Sciences, Pharmaceuticals and Medical Equipment

Contacts



Jessica Luedi
jessica.luedi@iwk.nshealth.ca
9024735315
Research Coordinator
Denise Lalanne
Business Development Manager

Equipment



Magnetoencephalography (MEG) Functional Neuroimaging System
Elekta Neuromag Oy
Vectorview

The Elekta Neuromag Vectorview is a whole-head 306-channel magnetoencephalography (MEG) neuroimaging system capable of measuring neural activity through biomagnetic signals generated by the human brain. It is used extensively in both research and clinical settings, within pediatric and clinical populations. Clinically, MEG is useful to non-invasively locate epileptogenic regions and perform pre-surgical functional mapping of sensation, motor and language functions. Due to its combination of temporal and spatial resolution, MEG is an exceptional technology for non-invasive imaging research on human brain function in healthy and patient populations.

The system contains 306 MEG channels (comprised of 204 planar gradiometers and 102 magnetometers), as well as an integrated 60 channel electroencephalography (EEG) system with optional input for 128 channels. The system provides whole-head coverage for neuromagnetic and neuroelectric, including coverage of the temporal lobes. Additionally, the integrated EEG system also includes 4 differential (i.e., bipolar) channels, enabling the simultaneous recording of electrocardiogram (ECG), electro-occulogram (EOG), and electromyogram (EMG). Data can be aligned with structural magnetic resonance images (MRI) to localize function to brain structures with sub-centimetre accuracy. Head shape digitization and continuous position monitoring allow for optimal registration of MEG/EEG to MRI.

A standard sampling rate of 5 kHz may be used with an optional maximum of 10 kHz. Ability to record in either the supine and seated positions are possible. Stimuli can be presented using visual, auditory, or tactile modalities. Participant responses can be logged using button pads or via intercom and video monitor.

2010

Clinical MRI system
GE Healthcare
MR750

To produce Magnetic Resonance Imaging (MRI) images in clinical settings for advanced applications in neuroimaging, body imaging, cardiac imaging and musculoskeletal (MSK) imaging. The system is a 50-50 joint research/clinical system with research activities supported by the BIOTIC imaging research group within the IWK/NSHA hospitals. Equipment specifications support specialized research activities for functional MRI, liver imaging, prostate imaging and quantitative MRI imaging, and involve the latest high speed image acceleration technologies including compressed sense imaging and multi-band EPI imaging.

Field Strength: 3 Tesla

Bore Size: 60 cm

Radiofrequency Coils:

32 channel Brain Coil

12 channel Head Neck Spine (HNS) Coil

32 channel Cardiac Coil

32 channel Body Coil

16 channel Flex Coil set (small, medium, large) for Musculoskeletal (MSK) imaging

Dual tuned (1H, 31P) brain coil for MR Spectroscopy

MRI scanner operates in research mode and can run customized MRI pulse sequences (software)

Pulse Sequences are fully complemented and optimized for neuroimaging, cardiac imaging, body imaging, and MSK imaging. Some examples include:

MR Elastography (liver stiffness)

Ideal IQ (quantitative liver fat and iron concentration)

Dynamic MRI imaging (DISCO) for Prostate, Liver and Brain perfusion/permeability imaging (2-4 second temporal resolution)

31P Spectroscopy (brain spectroscopy)

Proton Spectroscopy

Multi-band EPI imaging (resting state functional MRI)

T1 rho imaging (MSK applications)

Full complement of 2D and 3D T1, T2, T2* clinical imaging sequences

Human Connectome Project (HCP) specified pulse sequences and post-processing software pipelines (cortical folding, image registration, brain resting state networks)

Diffusion Tensor Imaging (DTI) tractography

Comprehensive Cardiac Imaging post-processing software packages

2014

Spectrophotometer
Molecular Devices
SpectraMax i3

Absorbance, fluorescence, and luminescence readings.

6 to 1536 wells, temperature control, Xenon flash lamp + high power LED as the light source

2016

3T MRI
Magnet Scientific
3T Agilent magnet

Magnetic resonance Imager (MRI) for small animals (mice, rats, etc.).

3T Aliment magnet with a 21cm ID gradient coil, interfaced with an Agilent DD console.

2007

PET/MRI insert
Cubresa Inc.
101792

A positon emission tomography (PET) imager that goes inside of our 3T MRI. Used for molecular imaging that generates 3D images of biochemical processes in live animals (mice & rats) using positron emission tomography.

NuPET 6620 system

75mm inner bore, offering a 56mm transaxial FOV

2016

PET/CT system
Gamma-Medica Ideas
CT – Trifoil Flex Triumph Pre-Clinical Imaging System; PET – LabPET

CT – pre-clinical system to perform in-vivo anatomical imaging of small animals using x-ray computer tomography (CT).

PET – a positon emission tomography (PET) scanner intended for small animal (mice & rats) high resolution 

functional imaging, using a labeled radionuclide pharmaceutical, to produce images of its internal 3D distribution.
2010

Single Photon Emission Computed Tomography (SPECT)
Cubresa Inc.
SRT50 – Spark SPECT

SPECT is used to track radionuclide compound distribution in vivo, and can also be paired with anatomical imaging techniques like Computed Tomography (CT) to quantify tracer concentrations in organs of interest.

2015

EEG
Brain Products
128-channel actiCHamp

Noninvasive test that records electrical patterns to help diagnose conditions such as head injuries, dizziness, headaches, epilepsy, brain tumors and sleeping problems.

  • 128-channel EEG.
  • Radio frequency and acoustically shielded room.
2015

Date submitted: Mon, Mar 6, 2017 12:09 PM
Date updated: Mon, Mar 6, 2017 12:09 PM

2018-04-09T04:17:10+00:00